Sixty nine years have now rolled on, since the institution came into being in 1952. It was a time when the medical facilities were practically out of reach for most people in Central Kerala. Impelled by the abiding spirit of the healing ministry of Jesus Christ and the awareness of the crying need of the sick and suffering, the Archdiocese of Trichur decided to take up the challenge. Thus, the organisation had a humble beginning on 17th December 1951, as a small dispensary. It began as a befitting memorial of the Sacerdotal Silver Jubilee of the late Bishop of Trichur Rt. Rev. Dr. George Alapatt, the first patron of the hospital. In 1952, the hospital started its service with four rooms and 20 beds, two retired part time doctors and two nurses of the Holy Cross Congregation, Sr. Albertina and Sr. Alfrida. This was the first and the only private hospital in Thrissur during the period.

At the time of inception, the hospital functioned in one part of the old building of St. Mary’s Minor Seminary, Thope, Thrissur. His Eminence Cardinal N. T. Gilroy of Australia blessed the very first hospital building on 30 th December 1952 in the presence of Card. V. Gracias. H. E. Martin Lucas SVD, the then Apostolic Internuncio to India inaugurated the institution on 23rd April, 1953. On the same year Cardinal Tisserant blessed the first operation theatre. It is 60 years since then that Jubilee Mission Hospital is rendering health care to the sick, irrespective of caste or creed, rich or poor.

The hospital experienced steady growth due to the committed and dedicated service of the doctors, nurses and other staff, the support of the general public and above all by the Divine Providence. Over the years JMMC&RI became synonym for cleft lip and palate surgery, treatment of snake bite and burns. The hospital opened up new horizons of health care to the common people from different parts of Thrissur, Palakkad and Malappuram with the addition of the super speciality departments of Cardiology and Nephrology in 1998. Other super speciality departments of Urology, Neurology, Neuro Surgery, Endocrinology, Micro Vascular Surgery, Cardio Thoracic Surgery etc. were soon added to the services of the hospital.

The School of Nursing started in the year 1966 and the hospital was recognized by the Medical Council of India (MCI) for internship Training of Doctors (CRRI) in the year 1971. In the year 2003, Jubilee Mission Hospital was recognized as a teaching hospital by the MCI and opened the Medical College. The College of Nursing was also founded in the same year, 2003. In 2011, MCI permitted the medical college to start PG medical courses. At present twelve specialities run PG courses.

The College of Nursing is recognized to commence M.Sc. Nursing in four specialities (Medical - Surgical, OBG, Child health and phychiatry) with a total intake of 10 seats and Post Basic Diploma in Cardio-Thoracic Nursing (annual intake of 15 seats) from 2012 onwards.

Today Jubilee Mission Medical College and Research Institute, Thrissur, a Christian minority Institution established and administered by the Jubilee Mission Hospital Trust, a charitable organization under the Archdiocese of Trichur has seven institutions placed under it :

1. Jubilee Mission Medical College Hospital (JMMCH)
2. Jubilee Mission Medical College & Research Institute(JMMC & RI)
3. Jubilee Mission College of Nursing (JMCON)
4. Jubilee Mission School of Nursing (JMSON)
5. Jubilee Mission College of Allied Health Sciences (JMCAHS)
6. Jubilee Centre for Medical Research (JCMR)
7. Jubilee Ayurveda Mission Hospital